H2N2V1, Main, Exploration, bibRecord, 002B07

Cell-mediated immune response to influenza virus infections in mice.

Identifieur interne : 002B07 ( Main/Exploration ); précédent : 002B06; suivant : 002B08

Cell-mediated immune response to influenza virus infections in mice.

Auteurs : G. Cambridge ; J S Mackenzie ; D. Keast

Source :

Infection and Immunity [ 0019-9567 ] ; 1976.

RBID : PMC:420574

Descripteurs français

KwdFr :
- Animaux, Immunité cellulaire, Inhibition de la migration cellulaire, Leucocytes, Lymphocytes (immunologie), Orthomyxoviridae (immunologie), Souris, Souris de lignée C3H, Spécificité des anticorps, Tests de cytotoxicité immunologique, Virus de la grippe A (croissance et développement), Virus de la grippe A (immunologie).
MESH :
- croissance et développement : Virus de la grippe A.
- immunologie : Lymphocytes, Orthomyxoviridae, Virus de la grippe A.
- Animaux, Immunité cellulaire, Inhibition de la migration cellulaire, Leucocytes, Souris, Souris de lignée C3H, Spécificité des anticorps, Tests de cytotoxicité immunologique.

English descriptors

KwdEn :
- Animals, Antibody Specificity, Cell Migration Inhibition, Cytotoxicity Tests, Immunologic, Immunity, Cellular, Influenza A virus (growth & development), Influenza A virus (immunology), Leukocytes, Lymphocytes (immunology), Mice, Mice, Inbred C3H, Orthomyxoviridae (immunology).
MESH :
- growth & development : Influenza A virus.
- immunology : Influenza A virus, Lymphocytes, Orthomyxoviridae.
- Animals, Antibody Specificity, Cell Migration Inhibition, Cytotoxicity Tests, Immunologic, Immunity, Cellular, Leukocytes, Mice, Mice, Inbred C3H.

Abstract

The local and systemic cell-mediated immune (CMI) responses to influenza virus infection in mice were examined by leukocyte migration inhibition and lymphocyte-mediated cytotoxicity tests. Mice were inoculated intranasally with 5 50% lethal doses of the A/WSN (H0N1) strain of influenza virus. Cells from the lymph nodes draining the upper and lower respiratory tract were used to measure the local response, and the spleen was the source of cells used for systemic determinations. The local response by pulmonary lymph node cells was greater and appeared earlier than was observed systemically in the spleen. The specificity of the CMI response was investigated by using a heterologous virus strain, A/Jap (H2N2), and recombinants A/Jap-NWS (H2N1) and A/NWS-Jap (H0N1), obtained from a cross between A/Jap (H2N2) and a virus, A/NWS (H0N1), with surface antigenic specificity similar to that of the inoculated virus. From the results of both tests used as correlates of CMI, it appeared that the response was specific against the hemagglutinin component of the inoculated virus. No reactivity was observed against the heterologous virus A/Jap (H2N2) nor against the recombinant A/Jap-NWS (H2N1) bearing the same neuradminidase as that of the inoculated virus.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420574

PubMed: 1248876
PubMed Central: 420574

Affiliations:

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<term>Immunity, Cellular</term>
<term>Influenza A virus (growth & development)</term>
<term>Influenza A virus (immunology)</term>
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<term>Lymphocytes (immunologie)</term>
<term>Orthomyxoviridae (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée C3H</term>
<term>Spécificité des anticorps</term>
<term>Tests de cytotoxicité immunologique</term>
<term>Virus de la grippe A (croissance et développement)</term>
<term>Virus de la grippe A (immunologie)</term>
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<front><div type="abstract" xml:lang="en"><p>The local and systemic cell-mediated immune (CMI) responses to influenza virus infection in mice were examined by leukocyte migration inhibition and lymphocyte-mediated cytotoxicity tests. Mice were inoculated intranasally with 5 50% lethal doses of the A/WSN (H0N1) strain of influenza virus. Cells from the lymph nodes draining the upper and lower respiratory tract were used to measure the local response, and the spleen was the source of cells used for systemic determinations. The local response by pulmonary lymph node cells was greater and appeared earlier than was observed systemically in the spleen. The specificity of the CMI response was investigated by using a heterologous virus strain, A/Jap (H2N2), and recombinants A/Jap-NWS (H2N1) and A/NWS-Jap (H0N1), obtained from a cross between A/Jap (H2N2) and a virus, A/NWS (H0N1), with surface antigenic specificity similar to that of the inoculated virus. From the results of both tests used as correlates of CMI, it appeared that the response was specific against the hemagglutinin component of the inoculated virus. No reactivity was observed against the heterologous virus A/Jap (H2N2) nor against the recombinant A/Jap-NWS (H2N1) bearing the same neuradminidase as that of the inoculated virus.</p>
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Serveur d'exploration H2N2

Cell-mediated immune response to influenza virus infections in mice.

Cell-mediated immune response to influenza virus infections in mice.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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